FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS) that is characterized by myelin damage, followed by axonal and ultimately neuronal loss, which has been found to be associated with mitophagy. The etiology and pathology of MS remain elusive. However, the role of FK506 binding protein 5 (FKBP5, also called FKBP51), a newly identified gene associated with MS, in the progression of the disease has not been well defined. Here, we observed that the progress of myelin loss and regeneration in Fkbp5^ko mice treated with demyelination for the same amount of time was significantly slower than that in wild-type mice, and that mitophagy plays an important regulatory role in this process. To investigate the mechanism, we discovered tha

SUBMITTER: Sun X 

PROVIDER: S-EPMC10640650 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature