Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection.

ABSTRACT:

Objective

The perturbation of tryptophan (TRP) metabolism has been linked with HIV infection and cardiovascular disease (CVD), but the interrelationship among TRP metabolites, gut microbiota, and atherosclerosis remain unclear in the context of HIV infection.

Methods

We included 361 women (241 HIV+, 120 HIV-) with carotid artery plaque assessments from the Women's Interagency HIV Study, measured 10 plasma TRP metabolites and profiled fecal gut microbiome. TRP metabolite-related gut bacteria were selected through the Analysis of Compositions of Microbiomes with Bias Correction method. Associations of TRP metabolites and related microbial features with plaque were examined using multivariable logistic regression.

Results

Although plasma kynurenic acid (KYNA) [odds ratio

SUBMITTER: Luo K 

PROVIDER: S-EPMC10640661 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature