Diagnosis of Crohn's disease and ulcerative colitis using the microbiome.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease resulting from dysregulation of the mucosal immune response and gut microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are difficult to distinguish, and differential diagnosis is essential for establishing a long-term treatment plan for patients. Furthermore, the abundance of mucosal bacteria is associated with the severity of the disease. This study aimed to differentiate and diagnose these two diseases using the microbiome and identify specific biomarkers associated with disease activity.

Results

Differences in the abundance and composition of the microbiome between IBD patients and healthy controls (HC) were observed. Compared to HC, the diversity of the gut microbiome i

SUBMITTER: Kang DY 

PROVIDER: S-EPMC10640746 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature