Neurological potency of native plants from sub-Himalayan West Bengal through reverse pharmacology.

ABSTRACT: Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and epilepsy, pose a growing global health challenge due to an aging population. These conditions share common processes, including protein accumulation, oxidative stress, and neuro-inflammation, making their treatment complex and costly. Network pharmacology, an innovative approach integrating systems biology and computational biology, offers insights into multi-target formulations and the repurposing of existing medications for neurodegenerative diseases. We shortlisted 730 bioactive compounds from 25 traditional Himalayan plants, assessed their drug-like properties using ADME criteria, and predicted their potential target proteins through reverse docking and pharmacophore mapping. Our study identifie

SUBMITTER: Tshering Dhendup L 

PROVIDER: S-EPMC10640792 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature