MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.

ABSTRACT:

Objective

This study explored the mechanism of squamous cervical cancer (SCC) progression.

Methods

Reverse transcription-quantitative polymerase chain reaction and western blotting were used to evaluate the expression of myosin light chain 9 (MYL9) in SCC tissues and cell lines. Furthermore, Transwell and Boyden assays were used to assess the function of MYL9 in SCC progression. In addition, the levels of lactate and aerobic glycolysis were used to explore the detailed mechanism of MYL9 in SCC.

Results

The mRNA and protein levels of MYL9 were elevated in SCC tissues, and MYL9 knockdown inhibited the migration and invasion of SCC cell lines. A mechanistic study demonstrated that MYL9 promotes SCC migration and invasion by enhan

SUBMITTER: Wen B 

PROVIDER: S-EPMC10640809 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature