Dynamic Resting-State Network Biomarkers of Antidepressant Treatment Response.

ABSTRACT:

Background

Delivery of effective antidepressant treatment has been hampered by a lack of objective tools for predicting or monitoring treatment response. This study aimed to address this gap by testing novel dynamic resting-state functional network markers of antidepressant response.

Methods

The Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study randomized adults with major depressive disorder to 8 weeks of either sertraline or placebo, and depression severity was evaluated longitudinally. Participants completed resting-state neuroimaging pretreatment and again after 1 week of treatment (n = 259 eligible for analyses). Coactivation pattern analyses identified recurrent whole-brain states of spatial coactivation, and computed

SUBMITTER: Kaiser RH 

PROVIDER: S-EPMC10640874 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature