Skeletal maturation and long-bone growth patterns of patients with progeria: a retrospective study.

ABSTRACT:

Background

Hutchinson-Gilford progeria syndrome (termed progeria in this Article) is a rare sporadic genetic disorder. One early clinical manifestation of progeria is abnormal skeletal growth, yet this growth has not been fully characterised. We aimed to characterise the skeletal maturation and long-bone growth patterns of patients with the clinical phenotype of progeria.

Methods

For this retrospective study, we reviewed skeletal surveys of patients (aged <20 years) with progeria obtained over a 9·5-year period. Most surveys included radiographs of the hands and long bones (humeri, radii, ulnas, tibias, and fibulas). Bone ages of these patients were estimated by the standards of Greulich and Pyle. Following the established methods for studying long-bone growth, the study coh

SUBMITTER: Tsai A 

PROVIDER: S-EPMC10640888 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature