Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis.

ABSTRACT: Pulmonary fibrosis (PF) is a devastating lung disease with limited treatment options. During this pathological process, the profibrogenic macrophage subpopulation plays a crucial role, making the characterization of this subpopulation fundamentally important. The present study revealed a positive correlation between pulmonary macrophages with higher mitochondrial mass (Mø^mitohigh) and fibrosis. Among the Mø^mitohigh subpopulation of CD206⁺ M2, characterized by higher expression of dynamin 1-like (Drp1), as determined by flow cytometry and RNA-seq analysis, a therapeutic intervention was developed using an exosome-based formula composed of pathfinder and therapeutics. A pathfinder exosome called "exosome^MMP19 (Exo^MMP19)", was cons

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10641087 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature