The role of inflammation in the effects of peer victimisation and stressful life events on mental health in childhood.

ABSTRACT: Peer victimisation represents a salient stressor during childhood. However, studies investigating the mechanism of its impact on children's mental health typically examine socio-cognitive factors as mediators. The current study sought to provide novel insight through testing a potential biological mechanism, inflammation. It also tested for pathway-specific effects by comparing how inflammation may mediate the effect of peer victimisation and that of another important stressor in childhood: adverse life events. Data from 4,583 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Path analysis was carried out to investigate whether inflammation (IL-6 and CRP) at age 9 years mediates the effect of peer victimisation and stressful life events at age 8 years

SUBMITTER: Roberts E 

PROVIDER: S-EPMC10641088 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature