Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases.

ABSTRACT: Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators. Deregulation of these regulatory molecules is associated with cell state transitions, which in turn is accountable for diverse maladies, including developmental disorders, metabolic disorders, and most significantly, cancer. A decade back most transcription factors, the key enablers of disease development, were historically viewed as 'undruggable'; however, in the intervening years, a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators, their confederates in various physiological and molecular processes. These co-activators, along with transcri

SUBMITTER: Talukdar PD 

PROVIDER: S-EPMC10641101 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature