Causal effects of gut microbiota on scoliosis: A bidirectional two-sample mendelian randomization study.

ABSTRACT:

Background

Recent studies have shown altered gut microbiome composition in patients with scoliosis. However, the causal effect of gut microbiota on scoliosis remains unknown.

Methods

A Mendelian randomization (MR) study was conducted to quantify the impact of 191 gut microbiome taxa's instrumental variables from the MibioGen Genome-wide association study (GWAS) on scoliosis risk using data from the FinnGen GWAS (1168 cases and 16,4682 controls). Inverse variance weighted (IVW) was the main method, and MR results were verified by sensitive analysis.

Results

Bilophila, Eubacterium (eligens group), Prevotella9, and Ruminococcus2 were discovered to have a protective effect on the risk of scoliosis. Ruminococcaceae UCG009, Catenibacterium

SUBMITTER: Lai B 

PROVIDER: S-EPMC10641244 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature