The type-2 Streptococcus canis M protein SCM-2 binds fibrinogen and facilitates antiphagocytic properties.

ABSTRACT: Streptococcus canis is a zoonotic agent that causes severe invasive diseases in domestic animals and humans, but little is known about its pathogenesis and virulence mechanisms so far. SCM, the M-like protein expressed by S. canis, is considered one of the major virulence determinants. Here, we report on the two distinct groups of SCM. SCM-1 proteins were already described to interact with its ligands IgG and plasminogen as well as with itself and confer antiphagocytic capability of SCM-1 expressing bacterial isolates. In contrast, the function of SCM-2 type remained unclear to date. Using whole-genome sequencing and subsequent bioinformatics, FACS analysis, fluorescence microscopy and surface plasmon resonance spectrometry, we demonstrate that, although different in amino ac

SUBMITTER: Lapschies AM 

PROVIDER: S-EPMC10641296 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature