Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study.

ABSTRACT:

Introduction

About two-thirds of the excess familial risk associated with breast cancer is still unaccounted for and may be explained by multiple weakly predisposing alleles. A gene thought to be involved in low-level predisposition to the disease is ERBB2 (HER2). This gene is involved in cell division, differentiation, and apoptosis and is frequently amplified in breast tumours. Its amplification correlates with poor prognosis. Moreover, the coding polymorphism I655V has previously been associated with an increased risk of breast cancer.

Methods

We aimed to determine if common polymorphisms (frequency >or= 5%) in ERBB2 were associated with breast cancer risk in a white British population. Five single-nucleotide polymorphisms (SNPs) were selected for study: SNP 1 near the pr

SUBMITTER: Benusiglio PR 

PROVIDER: S-EPMC1064135 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature