Tumor microbiome analysis provides prognostic value for patients with stage III colorectal cancer.

ABSTRACT:

Introduction

Although patients with colorectal cancer (CRC) can receive optimal treatment, the risk of recurrence remains. This study aimed to evaluate whether the tumor microbiome can be a predictor of recurrence in patients with stage III CRC.

Methods

Using 16S rRNA gene sequencing, we analyzed the microbiomes of tumor and adjacent tissues acquired during surgery in 65 patients with stage III CRC and evaluated the correlation of the tissue microbiome with CRC recurrence. Additionally, the tumor tissue microbiome data of 71 patients with stage III CRC from another center were used as a validation set.

Results

The microbial diversity and abundance significantly differed between tumor and adjacent tissues. In particular, Streptococcus and Gemella were mor

SUBMITTER: Kim JH 

PROVIDER: S-EPMC10641399 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature