Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review).

ABSTRACT: Immunotherapy has become one of the most promising approaches in tumor therapy, and there are numerous associated clinical trials in China. As an immunosuppressive tumor, head and neck squamous cell carcinoma (HNSCC) carries a high mutation burden, making immune checkpoint inhibitors promising candidates in this field due to their unique mechanism of action. The present review outlines a comprehensive multidisciplinary cancer treatment approach and elaborates on how combining immunochemotherapy and immunoradiotherapy guidelines could enhance clinical efficacy in patients with HNSCC. Furthermore, the present review explores the immunology of HNSCC, current immunotherapeutic strategies to enhance antitumor activity, ongoing clinical trials and the future direction of the current immune lands

SUBMITTER: Wei C 

PROVIDER: S-EPMC10641411 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature