Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality.

ABSTRACT: p97/valosin-containing protein is an essential eukaryotic AAA+ ATPase with diverse functions including protein homeostasis, membrane remodeling, and chromatin regulation. Dysregulation of p97 function causes severe neurodegenerative disease and is associated with cancer, making this protein a significant therapeutic target. p97 extracts polypeptide substrates from macromolecular assemblies by hydrolysis-driven translocation through its central pore. Growing evidence indicates that this activity is highly coordinated by "adapter" partner proteins, of which more than 30 have been identified and are commonly described to facilitate translocation through substrate recruitment or modification. In so doing, these adapters enable critical p97-dependent functions such as extraction of misfolded pr

SUBMITTER: Braxton JR 

PROVIDER: S-EPMC10641518 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature