Selective targeting and clustering of phosphatidylserine lipids by RSV M protein is critical for virus particle production.

ABSTRACT: Human respiratory syncytial virus (RSV) is the leading cause of infantile bronchiolitis in the developed world and of childhood deaths in resource-poor settings. The elderly and the immunosuppressed are also affected. It is a major unmet target for vaccines and antiviral drugs. RSV assembles and buds from the host cell plasma membrane by forming infectious viral particles which are mostly filamentous. A key interaction during RSV assembly is the interaction of the matrix (M) protein with cell plasma membrane lipids forming a layer at assembly sites. Although the structure of RSV M protein dimer is known, it is unclear how the viral M proteins interact with cell membrane lipids, and with which one, to promote viral assembly. Here, we demonstrate that M proteins are able to cluster at the pl

SUBMITTER: Swain J 

PROVIDER: S-EPMC10641529 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature