Potential contribution of the gut microbiota to the development of portal vein thrombosis in liver cirrhosis.

ABSTRACT:

Background

Portal vein thrombosis (PVT) is a serious complication of liver cirrhosis (LC) and is closely related to gut homeostasis. The study aimed to investigate the composition of gut microbiota and its putative role in PVT development in LC.

Methods

33 patients with LC admitted between January 2022 and December 2022 were enrolled in this study. Based on imaging findings, they were categorized into LC without PVT (n = 21) and LC with PVT (n = 12) groups. Fecal samples were collected from each participant and underwent 16S rDNA sequencing.

Results

D-Dimer and platelet elevations were the main clinical features of LC with PVT. The alpha and beta diversity of the gut microbiota in LC with PVT group was found to be significantly higher compared to the con

SUBMITTER: Huang XY 

PROVIDER: S-EPMC10641681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature