Scientific opinion on the tolerable upper intake level for folate.

ABSTRACT: Following a request from the European Commission (EC), the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the revision of the tolerable upper intake level (UL) for folic acid/folate. Systematic reviews of the literature were conducted to assess evidence on priority adverse health effects of excess intake of folate (including folic acid and the other authorised forms, (6S)-5-methyltetrahydrofolic acid glucosamine and l-5-methyltetrahydrofolic acid calcium salts), namely risk of cobalamin-dependent neuropathy, cognitive decline among people with low cobalamin status, and colorectal cancer and prostate cancer. The evidence is insufficient to conclude on a positive and causal relationship between the dietary intake of folate and impai

SUBMITTER: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA Panel) 

PROVIDER: S-EPMC10641704 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature