Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production.

ABSTRACT: Persistent inflammation and associated pain significantly impact individuals' quality of life, posing substantial healthcare challenges. Proinflammatory cytokines, released by activated macrophages, play crucial roles in the development of chronic inflammatory conditions such as rheumatoid arthritis. To identify and evaluate potential therapeutic interventions targeting this process for mitigating inflammation and pain, we created myeloid cell-specific knockout of Vamp3 (vesicle-associated membrane protein 3) mice (Vamp3 ^Δmyel) by crossing LysM-Cre mice with newly engineered Vamp3^flox/flox mice. Bone marrow-derived macrophages and peritoneal resident macrophages from Vamp3 ^Δmyel mice exhibited a significant reduction in TN

SUBMITTER: Dai X 

PROVIDER: S-EPMC10641732 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature