Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease.

ABSTRACT:

Background

Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance of proteins and discover novel targets for ischemic heart disease (IHD) and other diseases.

Objectives

The purpose of this study was to examine associations of proteomics and genetics data with IHD in population studies to discover novel preventive treatments.

Methods

We conducted a nested case-cohort study in the China Kadoorie Biobank (CKB) involving 1,971 incident IHD cases and 2,001 subcohort participants who were genotyped and free of prior cardiovascular disease. We measured 1,463 proteins in the stored baseline samples using the OLINK EXPLORE panel. Cox regression yielded adjusted HRs for IHD associated with individual proteins after ac

SUBMITTER: Mazidi M 

PROVIDER: S-EPMC10641761 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature