Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary cancer have higher survival rates than those with metastasis. Thus, it is imperative to discover biomarkers for the early detection of NSCLC and the timely prediction of tumor metastasis to improve patient outcomes.

Methods

Here, we utilized an integrated approach to isolate and characterize plasma exosomes from NSCLC patients as well as healthy individuals. We then conducted proteomics analysis and parallel reaction monitoring to identify and validate the top-ranked proteins of plasma exosomes.

Results

Our study revealed that the proteome in exosomes from NSCLC patients with

SUBMITTER: Luo B 

PROVIDER: S-EPMC10641949 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature