Design, spectral, molecular modeling, antimitotic, analytical and mechanism studies of phenyl isothiocyanate Girard's T derived metal complexes.

ABSTRACT: The ligand N-{[(phenyl amino) thioxomethyl] hydrazino carbonyl methyl} trimethyl ammonium chloride (PTHAC) was prepared by the refluxing phenyl isothiocyanate and Girard-T (trimethyl ammonium-acethydrazide) in a molar ratio (1:1). The metal complexes derived from NiCl₂.6H₂O, CuCl₂.2H₂O and Co(CH₃COO)₂.6H₂O were synthesized and purified. The PTHAC and its Cu(II), Co(II), and Ni(II) metal complexes(1-3) were characterized using a variety of various instrumental performances such as elemental analysis, magnetic moment, spectra (IR, UV-Vis, ¹H NMR, mass) and thermal analysis (TGA and DTG).The results of element analysis, magnetic moment, spectra (IR, UV-Vis, ¹H NMR, mass), and thermal (TGA and DT

SUBMITTER: Akl MA 

PROVIDER: S-EPMC10642003 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature