Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles.

ABSTRACT:

Background

Reports regarding the presence of bacteria in the fetal environment remain limited and controversial. Recently, extracellular vesicles secreted by the human gut microbiota have emerged as a novel mechanism for host-microbiota interaction. We aimed to investigate the presence of bacterial extracellular vesicles in the fetal environment during healthy pregnancies and determine whether extracellular vesicles derived from the gut microbiota can cross biological barriers to reach the fetus.

Results

Bacterial extracellular vesicles were detectable in the amniotic fluid of healthy pregnant women, exhibiting similarities to extracellular vesicles found in the maternal gut microbiota. In pregnant mice, extracellular vesicles derived from human maternal gut microbiota were

SUBMITTER: Kaisanlahti A 

PROVIDER: S-EPMC10642029 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature