Impact of clonal lineages on susceptibility of Staphylococcus lugdunensis to chlorhexidine digluconate and chloride benzalkonium.

ABSTRACT:

Background

Little is known about susceptibility of Staphylococcus lugdunensis to antiseptics. The objective of this study was to evaluate, at the molecular and phenotypic level, the susceptibility of 49 clinical S. lugdunensis strains (belonging to the seven clonal complexes [CCs] defined by multilocus sequence typing) to two antiseptics frequently used in healthcare settings (chlorhexidine digluconate [CHX] and chloride benzalkonium [BAC]).

Results

The minimum inhibitory concentrations (MICs), by broth microdilution method, varied for BAC from 0.25 mg/L to 8 mg/L (MIC₅₀ = 1 mg/L, MIC₉₀ = 2 mg/L) and for CHX from 0.5 mg/L to 2 mg/L (MIC₅₀ = 1 mg/L, MIC₉₀ = 2 mg/L). The BAC and CHX minimum bactericidal concentrations (MBCs) varied f

SUBMITTER: Destruel L 

PROVIDER: S-EPMC10642039 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature