Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI.

ABSTRACT:

Background

Understanding the pathological characteristics of various mild cognitive impairment (MCI) subtypes is crucial for the differential diagnosis of dementia. The purpose of this study was to feature divergent symptom-deficit profiles in amnestic MCI (aMCI) and non-amnestic MCI (naMCI).

Methods

T1 and DTI MRI data from a total of 158 older adults with 50 normal controls, 56 aMCI, and 52 naMCI were included. The voxel-wise gray matter volumes and the number of seed-based white matter fiber bundles were compared among these three groups. Furthermore, correlation and mediation analyses between the neuroimaging indices and cognitive measures were performed.

Results

The aMCI with specific memory abnormalities was characterized by volumetric atrophy of the left hippoc

SUBMITTER: Du C 

PROVIDER: S-EPMC10642051 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature