A systematic review of the development and application of home cage monitoring in laboratory mice and rats.

ABSTRACT:

Background

Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be influenced by various factors and valuable information may be missed when the animals are only monitored for short periods. These issues can be overcome by longitudinally monitoring mice and rats in their home cages. To shed light on the development of home cage monitoring (HCM) and the current state-of-the-art, a systematic review was carried out on 521 publications retrieved through PubMed and Web of Science.

Results

Both the absolute (~ × 26) and relative (~ × 7) number of HCM-related publications increased from 1974 to 2020. There was a clear bias towards ma

SUBMITTER: Kahnau P 

PROVIDER: S-EPMC10642068 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature