Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers.

ABSTRACT:

Background

Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and tumor progression. However, its prognostic significance across diverse cancer types remains relatively unexplored.

Methods

We conducted a comprehensive analysis of AURKA expression in various cancers using data from The Cancer Genome Atlas, Genotype-Tissue Expression, and The Human Protein Atlas databases. Our investigation encompassed an exploration of the associations between AURKA expression and clinical characteristics, shedding light on potential functional roles of AURKA. Additionally, we delved into the relationship between AURKA and the tumor microenvironment. To substantiate the role of AURKA, we carried out in vitro experiments in esophageal adenocarcinoma (EAC), prostate

SUBMITTER: Yang C 

PROVIDER: S-EPMC10642189 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature