Neural control of redox response and microbiota-triggered inflammation in Drosophila gut.

ABSTRACT:

Background

The neural system plays a critical role in controlling gut immunity, and the gut microbiota contributes to this process. However, the roles and mechanisms of gut-brain-microbiota interactions remain unclear. To address this issue, we employed Drosophila as a model organism. We have previously shown that NP3253 neurons, which are connected to the brain and gut, are essential for resistance to oral bacterial infections. Here, we aimed to investigate the role of NP3253 neurons in the regulation of gut immunity.

Methods

We performed RNA-seq analysis of the adult Drosophila gut after genetically inactivating the NP3253 neurons. Flies were reared under oral bacterial infection and normal feeding conditions. In addition, we prepared samples under germ-free

SUBMITTER: Fuse N 

PROVIDER: S-EPMC10642236 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature