Mediating effect of depression on the association between cardiovascular disease and the risk of all-cause mortality: NHANES in 2005-2018.

ABSTRACT:

Background

Cardiovascular disease (CVD) patients are more likely to have depression than general populations, and meanwhile, depression increased all-cause mortality. However, the interaction effect of depression on CVD and all-cause mortality has not been reported yet.

Hypothesis

Herein, we speculate that depression may play an intermediate role in the association of CVD and all-cause mortality.

Methods

Demographic and clinical data of 33,156 adults (≥20 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2005-2018 in this retrospective cohort study. Weighted univariate and multivariate COX regression analyses were used to screen the covariates and to explore the relationship of CVD and depression. Distribution-of-

SUBMITTER: Ma X 

PROVIDER: S-EPMC10642320 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature