Increased small extracellular vesicle levels and decreased miR-126 levels associated with atrial fibrillation and coexisting diabetes mellitus.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Diabetes mellitus (DM) is one of the risk factors for the development of stroke and thromboembolism in patients with AF. Early identification may reduce the incidence of complications and mortality in AF patients.

Hypothesis

AF patients with DM have different pattern of small extracellular vesicle (sEV) levels and sEV-derived microRNA (miRNA) expression compared with those without DM.

Methods

We compared sEV levels and sEV-miRNA expression in plasma from AF patients with and without DM using nanoparticle tracking analysis and droplet digital polymerase chain reaction, respectively.

Results

We observed a significant increase in total sEV levels (p = .004) and a significant decrease in

SUBMITTER: Siwaponanan P 

PROVIDER: S-EPMC10642338 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature