Novel role for alpha-2-macroglobulin (A2M) as a disease modifying protein in senile osteoporosis.

ABSTRACT: Introduction: In the rapidly aging U.S. population, age-induced bone loss (senile osteoporosis) represents a major public health concern that is associated with a significant increased risk for low trauma fragility fractures, which are debilitating to patients, cause significant morbidity and mortality, and are costly to treat and manage. While various treatments exist to slow bone loss in osteoporosis patients, these suffer from poor tolerability and label restrictions that limit their overall effectiveness. Over the past decade, skeletal stem/progenitor cells (SSPCs), which are the main precursor of osteoblasts and adipocytes in adult bone marrow (BM), have emerged as important players in osteoporosis. Methods: Age-induced skeletal pathology was quantified in elderly (24-mo

SUBMITTER: Boregowda SV 

PROVIDER: S-EPMC10642388 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature