Modulators of a robust and efficient metabolism: Perspective and insights from the Rid superfamily of proteins.

ABSTRACT: Metabolism is an integrated network of biochemical pathways that assemble to generate the robust, responsive physiologies of microorganisms. Despite decades of fundamental studies on metabolic processes and pathways, our understanding of the nuance and complexity of metabolism remains incomplete. The ability to predict and model metabolic network structure, and its influence on cellular fitness, is complicated by the persistence of genes of unknown function, even in the best-studied model organisms. This review describes the definition and continuing study of the Rid superfamily of proteins. These studies are presented with a perspective that illustrates how metabolic complexity can complicate the assignment of function to uncharacterized genes. The Rid superfamily of proteins has been div

SUBMITTER: Fulton RL 

PROVIDER: S-EPMC10642521 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature