Spin dynamics of [1,2-¹³C₂]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields.

ABSTRACT: Hyperpolarization of ¹³C-pyruvate via Signal Amplificaton By Reversibble Exchange (SABRE) is an important recent discovery because of both the relative simplicity of hyperpolarization and the central biological relevance of pyruvate as a biomolecular probe for in vitro or in vivo studies. Here, we analyze the [1,2-¹³C₂]pyruvate-SABRE spin system and its field dependence theoretically and experimentally. We provide first-principles analysis of the governing 4-spin dihydride-¹³C₂ Hamiltonian and numerical spin dynamics simulations of the 7-spin dihydride-¹³C₂-CH₃ system. The analytical and the numerical results are compared to matching systematic experiments. With these methods we unr

SUBMITTER: Browning A 

PROVIDER: S-EPMC10642564 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature