Associations between collagen X biomarker and linear growth velocity in a pediatric chronic kidney disease cohort.

ABSTRACT:

Background

Collagen X biomarker (CXM) is a novel biomarker of linear growth velocity. We investigated whether CXM correlated with measured growth velocity in children with impaired kidney function.

Methods

We used data from children aged 2 through 16 years old enrolled in the Chronic Kidney Disease in Children (CKiD) study. We assessed the association between CXM level and growth velocity based on height measurements obtained at study visits using linear regression models constructed separately by sex, with and without adjustment for CKD covariates. Linear mixed-effects models were used to capture the between-individual and within-individual CXM changes over time associated with concomitant changes in growth velocity from baseline through follow-up.

Results

A total of

SUBMITTER: Brown DD 

PROVIDER: S-EPMC10642619 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature