Chlamydia trachomatis and the HLA involvement in the development of infection and disease: a narrative review.

ABSTRACT: CT (Chlamydia trachomatis) is among the most common pathogens leading to sexually transmitted diseases. Considering the uncertain mechanism by which HLA polymorphisms influence the CT infection, reinfection, comorbidities or evolution and because there is no consensus regarding the alleles involved in the pathogenesis of the infection, we considered necessary to perform a review to summarize the current knowledge of HLA related to CT. Pubmed was researched using key terms. Out of the 198 results found, we analyzed articles of all types which describe how the MHC, through HLA alleles, participates in the different stages of CT penetration in the body, including studies about cells or other molecules involved in the process. Almost 40% of the variation in the clinical course of CT infection

SUBMITTER: Pintea-Trifu ML 

PROVIDER: S-EPMC10642737 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature