The association between human blood clot analogue computed tomography imaging, composition, contraction, and mechanical characteristics.

ABSTRACT:

Background

Clot composition, contraction, and mechanical properties are likely determinants of endovascular thrombectomy success. A pre-interventional estimation of these properties is hypothesized to aid in selecting the most suitable treatment for different types of thrombi. Here we determined the association between the aforementioned properties and computed tomography (CT) characteristics using human blood clot analogues.

Methods

Clot analogues were prepared from the blood of 4 healthy human donors with 5 red blood cell (RBC) volume suspensions: 0%, 20%, 40%, 60% and 80% RBCs. Contraction was measured as the weight of the contracted clots as a percentage of the original suspension. The clots were imaged using CT with and without contrast to quantify clot density and dens

SUBMITTER: Cruts JMH 

PROVIDER: S-EPMC10642823 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature