Gene coexpression network analysis reveals perirenal adipose tissue as an important target of prenatal malnutrition in sheep.

ABSTRACT: We have previously demonstrated that pre- and early postnatal malnutrition in sheep induced depot- and sex-specific changes in adipose morphological features, metabolic outcomes, and transcriptome in adulthood, with perirenal (PER) as the major target followed by subcutaneous (SUB) adipose tissue. We aimed to identify coexpressed and hub genes in SUB and PER to identify the underlying molecular mechanisms contributing to the early nutritional programming of adipose-related phenotypic outcomes. Transcriptomes of SUB and PER of male and female adult sheep with different pre- and early postnatal nutrition histories were used to construct networks of coexpressed genes likely to be functionally associated with pre- and early postnatal nutrition histories and phenotypic traits using weighted gen

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC10642927 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature