A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories.

ABSTRACT: The latest 2021 WHO classification redefines glioblastoma (GBM) as the hierarchical reporting standard by eliminating glioblastoma, IDH-mutant and only retaining the tumor entity of "glioblastoma, IDH-wild type." Knowing that subclassification of tumors based on molecular features is supposed to facilitate the therapeutic choice and increase the response rate in cancer patients, it is necessary to carry out molecular classification of the newly defined GBM. Although differentiation trajectory inference based on single-cell sequencing (scRNA-seq) data holds great promise for identifying cell heterogeneity, it has not been used in the study of GBM molecular classification. Single-cell transcriptome sequencing data from 10 GBM samples were used to identify molecular classification based on di

SUBMITTER: Zhang G 

PROVIDER: S-EPMC10643041 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature