Antenatal Magnesium Sulfate Is Not Associated With Improved Long-Term Neurodevelopment and Growth in Very Low Birth Weight Infants.

ABSTRACT:

Background

Though antenatal magnesium sulfate (MgSO₄) is widely used for fetal neuroprotection, suspicions about the long-term neuroprotection of antenatal MgSO₄ have been raised.

Methods

We investigated short- and long-term outcomes of antenatal MgSO4 use for 468 infants weighing < 1,500 g with a gestational age of 24-31 weeks.

Results

Short-term morbidities and the risk of developmental delay, hearing loss, and cerebral palsy at a corrected age of 18-24 months and 3 years of age did not decrease in the MgSO₄ group (infants who were exposed to MgSO₄ for any purpose) or neuroprotection group (infants who were exposed to MgSO₄ for fetal neuroprotection) compared with the control group (infants who were not exposed

SUBMITTER: Jeon GW 

PROVIDER: S-EPMC10643250 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature