Anti-HER2 Drugs for the Treatment of Advanced HER2 Positive Breast Cancer.

ABSTRACT:

Opinion statement

Approximately 15-20% of breast cancers (BC) demonstrate HER2 overexpression/gene amplification. Historically, before the era of HER2-directed therapies, this subtype was associated with poor prognosis. Anti-HER2 agents dramatically changed the natural course of disease and significantly prolonged patients' survival. In recent years, a number of new anti-HER2 therapies have been developed, and their approvals offer new therapeutic options for patients with advanced HER2-positive breast cancer. At present, HER2 pathway blocking drugs used in the treatment of metastatic breast cancer worldwide include trastuzumab and pertuzumab in the first-line treatment; trastuzumab deruxtecan and trastuzumab emtansine in the second line; and tucatinib, neratinib, lapatinib, and ma

SUBMITTER: Stanowicka-Grada M 

PROVIDER: S-EPMC10643304 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature