Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity.

ABSTRACT:

Objective

The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression occurring in response to highly caloric food or interoceptive energy need. However, the interoceptive mechanisms priming an appropriate AgRP neural response to external sensory information of food availability remain unexplored. Since hunger increases plasma ghrelin, we hypothesized that ghrelin receptor (GHSR) signalling on AgRP neurons is a key interoceptive mechanism integrating energy need with external sensory cues predicting caloric availability.

Methods

We used in vivo photometry to measure the effects of ghrelin administration or fasting on AgRP neural activity with GCaMP6s and dopamine release in the nucleus

SUBMITTER: So WL 

PROVIDER: S-EPMC10643323 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature