Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans.

ABSTRACT: Thymic epithelial cells (TECs) play a critical role in thymic development and thymopoiesis. As individuals age, TECs undergo various changes that impact their functions, leading to a reduction in cell numbers and impaired thymic selection. These age-related alterations have been observed in both mice and humans. However, the precise mechanisms underlying age-related TEC dysfunction remain unclear. Furthermore, there is a lack of a comprehensive study that connects mouse and human biological processes in this area. To address this gap, we conducted an extensive transcriptome analysis of young and old TECs in mice, complemented by further analysis of publicly available human TEC single-cell RNA sequencing data. Our analysis revealed alterations in both known and unknown pathways that potenti

SUBMITTER: Lee S 

PROVIDER: S-EPMC10643332 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature