⁶⁸Ga-PSMA-PET/CT in addition to mpMRI in men undergoing biopsy during active surveillance for low- to intermediate-risk prostate cancer: study protocol for a prospective cross-sectional study.

ABSTRACT:

Background

In active surveillance there is significant interest in whether imaging modalities such as multiparametric magnetic resonance imaging (mpMRI) or ⁶⁸Gallium prostate-specific membrane antigen positron emission tomography/computerized tomography (⁶⁸Ga-PSMA-PET/CT) can improve the detection of progression to clinically significant prostate cancer (csPCa) and thus reduce the frequency of prostate biopsies and associated morbidity. Recent studies have demonstrated the value of mpMRI in active surveillance; however, mpMRI does miss a proportion of disease progression and thus alone cannot replace biopsy. To date, prostate-specific membrane antigen positron emission tomography (PSMA-PET) has shown additive value to mpMRI in its ability to detect prostate ca

SUBMITTER: Gondoputro W 

PROVIDER: S-EPMC10643393 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature