Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke.

ABSTRACT: Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of drugs for the treatment of stroke, as global deletion of this gene in mice significantly protected against ischemic damage. In the current study, we demonstrate that small molecular weight IRAP inhibitors reduce infarct volume and improve neurological outcome in a hypertensive animal model of ischemic stroke. The effects of two structurally distinct IRAP inhibitors (HFI419 or SJM164) were investigated in a model of stroke where the middle cerebral artery was transiently occluded with endothelin-1 in the conscious spontaneously hypertensive rat. IRAP inhib

SUBMITTER: Telianidis J 

PROVIDER: S-EPMC10643421 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature