Association of per- and polyfluoroalkyl substance exposure with metabolic syndrome and its components in adults and adolescents.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are widespread contaminants, but few studies have explored the relationship between PFAS and levels of metabolic syndrome (MetS) in the population. The available evidence of an association is also conflicting. We selected adults and adolescents with complete PFAS data from the National Health and Nutrition Examination Survey conducted between 2003 and 2018. We analyzed the association between PFAS and MetS using multivariate logistic regression models and evaluated potential nonlinear relationships with restricted cubic spline models. Additionally, we employed weighted quantile sum (WQS) regressions to uncover the multiple exposure effects and relative weights of each PFAS. Finally, we conducted a series of sensitivity analyses to test the robustn

SUBMITTER: Zheng H 

PROVIDER: S-EPMC10643431 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature