Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging.

ABSTRACT: The liver, as a crucial metabolic organ, undergoes significant pathological changes during the aging process, which can have a profound impact on overall health. To gain a comprehensive understanding of these alterations, we employed data-driven approaches, along with biochemical methods, histology, and immunohistochemistry techniques, to systematically investigate the effects of aging on the liver. Our study utilized a well-established rat aging model provided by the National Institute of Aging. Systems biology approaches were used to analyze genome-wide transcriptomics data from liver samples obtained from young (4-5 months old) and aging (20-21 months old) Fischer 344 rats. Our findings revealed pathological changes occurring in various essential biological processes in aging livers. Th

SUBMITTER: Arif M 

PROVIDER: S-EPMC10643490 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature