RRP12 suppresses cell migration and invasion in colorectal cancer cell via regulation of epithelial-mesenchymal transition.

ABSTRACT:

Background

The survival of patients with advanced colorectal cancer (CRC) is variable. The high rates of recurrence, metastasis, and drug resistance make clinical treatment difficult, which needs to further develop therapeutic and prognostic targets. Ribosomal RNA processing 12 homolog (RRP12), as a nucleolar protein involved in ribosome subunit maturation and export, plays important roles in cell cycle-related processes and the response to DNA damage, and regulates the occurrence and development of various cancers. The primary aim of this study was to identify the function of RRP12 in the process of epithelial-mesenchymal transition (EMT) in CRC.

Methods

In this study, the expression of RRP12 in tissue samples and the association with clinicopathological features in CRC was

SUBMITTER: An G 

PROVIDER: S-EPMC10643574 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature