Cadherin dysregulation in gastric cancer: insights into gene expression, pathways, and prognosis.

ABSTRACT: The Cadherin gene family holds immense significance in maintaining the integrity and functionality of stomach tissues, playing crucial roles in cell-cell adhesion, cell migration and differentiation. Dysregulation of cadherin expression and function has been closely associated with various gastric diseases, particularly gastric cancer (GC). Understanding the regulation and clinical implications of cadherin genes in GC is essential to improve our knowledge and to identify new potential prognostic markers and therapeutic targets. In this study, we provide an overview on the role of cadherin family genes in GC using bioinformatics analysis. We analyzed the expression, mutational status, and prognostic value of these genes based on available public datasets. Our methodology involved data minin

SUBMITTER: Wang H 

PROVIDER: S-EPMC10643585 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature