Impact of maternally derived meiotic aneuploidies on early embryonic development in vitro.

ABSTRACT:

Purpose

To assess early embryonic developmental potential of embryos affected by maternally inherited meiotic aneuploidies.

Methods

This observational, descriptive study includes 930 oocytes from 151 patients which were retrospectively analyzed by combining the morphological assessment with the genetic results from polar body diagnosis.

Results

Of 930 oocytes examined, 566 (60.9%) were tested aneuploid. Developmental potential until cleavage stage was not affected by trisomies or monosomies (69.6% vs. 77.1%, p = 0.75). However, trisomies significantly more often resulted in top quality cleavage stage embryos compared to monosomies (20% vs. 17.6%, p =  < 0.01). Top quality blastocysts were more likely to be euploid than aneuploid (52.4% vs. 47.6%, p = 0.032). Additiona

SUBMITTER: Tschare L 

PROVIDER: S-EPMC10643722 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature